Glaucoma & Sleep Apnea

The Background

Over the last several years, research has indicated a strong correlation between the presence of Obstructive Sleep Apnea (OSA) and glaucoma. Information from some of these pivotal studies is presented below.

Did you know

  • Glaucoma affects over 60 million people worldwide and almost 3 million people in the U.S.
  • There are many people who have glaucoma but have not yet had it diagnosed.
  • Glaucoma is a leading cause of blindness in the United States. 
  • If glaucoma is not detected and goes untreated, it will result in peripheral vision loss and eventual, irreversible blindness.

  • Sleep apnea is a condition that obstructs breathing during sleep.
  • It affects 100 million people around the globe and around 25 million people in the U.S.
  • A blocked airway can cause loud snoring, gasping or choking because breathing stops for up to two minutes.
  • Poor sleep due to sleep apnea results in morning headaches and chronic daytime sleepiness.

The Studies

In January 2016, a meta-analysis by Liu et. al., reviewed studies that collectively encompassed 2,288,701 individuals over six studies. Review of the data showed that if an individual has OSA there is an increased risk of glaucoma that ranged anywhere from 21% to 450% depending on the study.

Later in 2016, a study by Shinmei et al. measured the intraocular pressure in subjects with OSA while they slept and had episodes of apnea. Somewhat surprisingly they found that when the subjects were demonstrating apnea during sleep, their eye pressures were actually lower during those events than when the events were not happening.

This does not mean there is no correlation between sleep apnea and glaucoma - it just means that an increase in intraocular pressure is not the causal reason for this link. It is much more likely that the correlation is caused by a decrease in the oxygenation level (which happens when you stop breathing) in and around the optic nerve.

In September of 2016, Chaitanya et al. produced an exhaustive review of all the studies done to date regarding a connection between obstructive sleep apnea and glaucoma and came to a similar conclusion. The risk for glaucoma in someone with sleep apnea could be as high as 10 times normal. They also concluded that the mechanism of that increased risk is most likely hypoxia – or oxygen deficiency - to the optic nerve.

The Conclusion

There seems to be a definite correlation of having obstructive sleep apnea and a significantly increased risk of getting glaucoma. That risk could be as high as 10 times the normal rate.

It's highly recommended that if you have been diagnosed with obstructive sleep apnea that you have have a comprehensive eye exam in order to detect your potential risk for glaucoma.

What Tests Might I Have During My Eye Exam?

Visual Field

The visual field test is designed to see how well you see outside of the center part of your vision (peripheral vision).

When we test your vision on the basic eye chart it is only testing how well you see right in the center and gives us no idea if you can see out away from the center. Your peripheral vision is very important because it gives you the ability to move around your environment without running into things.

There are several diseases that can severely impact your peripheral vision while leaving central vision unaffected. Some people can have perfectly normal 20/20 central visual acuity and have almost complete loss of their peripheral vision.

The main culprits that can have a big impact on your peripheral vision long before your central vision are glaucoma, some retinal diseases such as retinal detachments or retinitis pigmentosa, and some neurological problems like brain tumors, strokes, pseudotumor cerebri and multiple sclerosis.  

Most visual field tests are now done on an automated machine that flashes lights in your peripheral vision while you stare straight ahead. The lights continue to get dimmer until you can no longer detect that they are there. The machine is trying to find the dimmest light you can see at each point in your peripheral vision that it is testing for.

Many patients get anxious when they take this test because everyone wants to do well on it. That sometimes results in people not staring straight ahead but trying to look around to find the lights in an effort to do better.

That just makes the test come out worse. The machine also makes some noise as it changes location of the test light. Some people start pressing the buzzer whenever they hear a noise. They think there must be a light they missed but the machine, several times during the test, makes noise and then doesn’t put a light on to specifically see if you are trying to cheat by hitting the buzzer on the noise rather that seeing the light. Don’t do those things - you are only cheating yourself and making it more difficult to figure out your problem.

Ocular Coherence Tomography (OCT)

The OCT really took hold in eye doctors' offices at the beginning of this century. It was the first time we were able to see anatomy and pathology inside the eye on a microscopic level without the use of any radiation.

It has been a great addition to our examination techniques and allowed us to see many causes of vision loss at a level of detail we could never have before.

The two biggest uses for OCT in optical health are diagnosing diseases of the retina, particularly the area of central vision called the macula, and for diseases of the optic nerve, the most common of which is glaucoma.

For retinal disease it has been extremely helpful in macular problems such as macular degeneration, the leading cause of blindness in the U.S., diabetic retinopathy, retinal vascular occlusions and retinal swelling from inflammation.

The OCT allows us to see the individual cellular levels of the retina and helps in diagnosing the exact level where the pathology is occurring. If you look into the eye at the retina and see some bleeding in the macula it is difficult to judge where that blood exists. Is it superficial in the retina and coming from the retinal circulation or is it deep in and coming from the choroidal circulation under the retina?

The difference between those two locations can have a significant impact on what disease is causing the problem and what the proper treatment is. The OCT is also very helpful in following the effect of treatment. If you are treating a bleeding or swelling problem in the retina, the OCT can track the degree of improvement with a level of detail that could never be matched by the human eye.

For glaucoma and other problems with the optic nerve, the OCT can very precisely measure the thickness of the nerve tissue as it passes through the optic nerve. The hallmark of glaucoma is progressive loss of nerve fibers in the optic nerve.  Being able to measure the nerve thickness down to the micron level is very helpful in both diagnosing and watching for progression of any optic nerve disease.

Fundus Photography

A picture is worth 1,000 words...

Fundus photography is just that, a regular picture of the inside of your eye. The pictures highlight the appearance of the macula and the optic nerve and record it for prosperity.

As eye doctors we make notes in the medical record of what we see when we look in the eye. The wording of anything that looks abnormal with the retina or optic nerve does vary somewhat from doctor to doctor. One of things we record is something called the cup to disk ratio (C:D) of the optic nerve. We express that ratio as a percentage. Normal is about 30% or .3. The range of normal is very wide and some “normal” eyes have a .1 cup and others can have a .7.

In glaucoma those percentages get larger over time as the person loses nerve tissue. So, if you were born with a .3 cup but in your 60’s you were found to have a .5 cup that would be a strong indicator that you might have glaucoma.  However, if you were born with a .5 cup and at 60 you still have a .5 cup then you don’t have glaucoma.  When you look at someone at 60 with a .5 cup it’s hard to be sure if this is normal for that person or did they progress from a .3 cup to a .5 cup.  If only I had a picture …  

Pictures of the back of the eye really do tell the story better than words. I can describe what the C:D looks like to me but a different doctor may describe it differently. Doctors are usually fairly consistent in their estimate of the C:D when it is the same doctor watching that C:D over time. When a different doctor estimates the C:D that consistency is just not there. My .4 C:D may be my partner’s .5. But you can’t argue with the picture.  

The same thing occurs with retinal bleeding. Rating the amount of bleeding as mild, moderate or severe is somewhat helpful but there is a broad range of “mild” or “moderate”. When comparing two pictures taken at two different points of time it is much easier to decide if something is really getting better or worse.

We also use fundus photography to keep an eye on small tumors that can develop in the eye called choroidal nevi. These are increased areas of pigmentation under the retina in an area called the choroid. Most eye doctors explain these pigmented spots a “freckles in the eye”.  Most choroidal nevi are small and fairly flat. They can, however, sometimes grow larger and rarely turn into a melanoma in the eye. Serial photographs are very helpful in watching the lesions for growth.

These three tests - visual field, OCT and fundus photography - make up the core of our testing. There are many other tests that can be performed along with your eye exam but these three we described here probably make up about 80% of the tests you may encounter, depending on your individual problem.

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Mission Statement

Our doctors and staff are committed to providing thorough care with personal attention. At Eye Doctors of Madison, you will find the compassionate care of a small-town doctors' office with the knowledge of a big-city institution. It is our mission to not only treat each patient uniquely but also like family.

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